Product: 2-phenylacetamide
Formulae hypotheticae: C8H9NO
Pondus hypotheticum: 135.17
Nomen anglicum: Phenylacetamide
Character: lanula alba vel folium crystallis informibus.Mp 157-158 ℃, bp 280-290 (compositio).Solutum in aqua calida et ethanol, leviter solutum in aqua frigida, aethere, et benzene.
Usus: Intermedia medicamentorum sicut penicillinum et phenobarbitale.Ponitur etiam ad praeparationem acidi phenylacetici, aromatis et pesticidis.
Modus 1) Masuko F，Katsura T.US 4536599A1.1985.
Adde 117.2 g (1.0 mol) phenylacetonitrile (2), 56.1 g 25% solutionis hydroxidi potassii, 291.5 g 35% hydrogenii peroxidi solutionem aqueam, 1.78 g benzyltriethylammonium chloridum, et 351.5 g isopropanolum ad reactionem lagona.Excita et agere in 50 pro 4 horis.Post reactionem absolvitur, isopropanol evaporatur sub pressura redacta, aqua refrigerata, percolata, lota et siccata ad compositam obtinendam (1) 128.5 g, mp 155 , cum redditu 95%.
Methodus 2) Furniss BS，Hannaford AJ，Rogers V，et al.Vogel's Textbook of Practical Chemistry. Longman London and New York.
Adde 100 g (0.85 mol) phenylacetonitrili (2) et 400 mL acidi hydrochlorici contracti ad reactionem lagona.Suscitans, reagit ad 40 obolum circiter 40 minutas, et temperatura ad 50 levabit.Permanere agere pro XXX minutis.Refrigescant ad 15 , et adde 400 mL aquae destillatae frigidae destillatae.Aqua refrigerans in glacie balneum, crystallis percolando.Adde solidum ad 50 mL aquae et ad acidum phenylaceticum penitus tollendum.Filter et siccum in 50-80 obtinere 95 g phenylacetamidei (1), mp 154-155 , cum proventu 82%.Recrystallization with ethanol, mp 156 .
Post tempus: Apr-11-2023